Abstract
Stability study of ceftazidime was realized in order to investigate kinetics of degradation of this drug both in powder for injection and reconstituted sample. Ceftazidime was submitted to conditions of accelerated thermal degradation and photodegradation. Analyses of the degraded samples were performed by microbiological assay and decomposition reactions could be described by zero-order and second-order kinetics. Results obtained confirm the reliability of the microbiological assay for determination of ceftazidime by the presence of its degradation products. The present study revealed thermal and photo lability of the drug, especially as reconstituted sample, and protection is recommended during storage and handling.
Highlights
Ceftazidime is a third-generation cephalosporin widely used for the treatment of serious infections caused by Stability is defined as the capacity of a drug substance or drug product to remain within established specifications to maintain its identity, strength, quality, and purity throughout the retest or expiration dating periods[1,2,3].Due to their possible composition, pharmaceuticals areGram-negative bacteria, including Pseudomonas aeruginosa, especially in cystic-fibrosis patients
The aim of this study was to evaluate the stability of ceftazidime in powder for injection and reconstituted sample against several stress conditions, such as temperature and both ultraviolet and visible radiation to determine the kinetics of degradation, describing concentration changes of ceftazidime as a function of time, as well as the kinetics run parameters
Ceftazidime reference substance and ceftazidime powder for injection were kindly supplied by Ariston Química e Farmacêutica Ltda. (São Paulo, Brazil)
Summary
Ceftazidime is a third-generation cephalosporin widely used for the treatment of serious infections caused by Stability is defined as the capacity of a drug substance or drug product to remain within established specifications to maintain its identity, strength, quality, and purity throughout the retest or expiration dating periods[1,2,3].Due to their possible composition, pharmaceuticals areGram-negative bacteria, including Pseudomonas aeruginosa, especially in cystic-fibrosis patients. Ceftazidime is a third-generation cephalosporin widely used for the treatment of serious infections caused by Stability is defined as the capacity of a drug substance or drug product to remain within established specifications to maintain its identity, strength, quality, and purity throughout the retest or expiration dating periods[1,2,3]. Due to their possible composition, pharmaceuticals are. Drug stability is considered to be a secure way to ensure delivery of therapeutic values to patients[4]
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