Abstract
A region affecting the pBR322 plasmid maintenance has been located within the region of the Tc R gene promoter. On the basis of stability analysis of pBR322 derivatives comprising the modified region of the Tc R gene, we deduced that it is the nucleotide sequence localized in the region of the HindIII site that causes destabilization of the plasmid and not the Tc R gene product or active transcription of this region. The destabilizing effect is manifested both in cis and in trans.
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