Abstract
Stability of poly(acrylic acid)-complexed dipalmitoylphosphatidylcholine vesicles was investigated at various temperatures, pHs, ionic strengths, and glucose concentrations of the dispersion medium. The vesicle stability as estimated by the release of fluorescent marker decreased appreciably above the phase transition temperature of dipalmitoylphosphatidylcholine. Marker release increased with increasing pH of the medium. suggesting an important contribution of hydrogen bonding between undissociated carboxyl groups of poly(acrylic acid) and phosphodiester head groups of dipalmitoylphosphatidylcholine to the interactions of these components of the vesicle membrane. An increase in glucose concentration brought about a pronounced decrease in percentage marker release, demonstrating that the increased osmotic pressure of the glucose solution prevents the marker from moving out of the vesicles. As the ionic strength of the medium increased, the percentage marker release decreased significantly. Accordingly, a proposal was put forward to show that glucose concentration and ionic strength exert a similar effect on vesicle stability. In fact, a linear relationship was found to hold between glucose concentration and ionic strength that produces idential percentages of marker release.
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