Abstract
A kinetic study of the proton catalyzed hydrolysis of atropine has been carried out and the temperature dependency of this reaction established. The constants obtained for this reaction have been combined with those previously reported for the hydroxyl catalyzed reactions and an equation proposed to predict the half life of atropine undergoing hydrolysis at constant pH and temperature. The pH of minimum hydrolysis has been calculated and found to vary with temperature from pH 4.11 at 0° to pH 3.24 at 100°. Calculated half lives of atropine in solution over the region of pH 2 to 7 at temperatures from 20° to 100° are given.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the American Pharmaceutical Association (Scientific ed.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
