Abstract
A simple, specific, accurate and stability-indicating Ultra Violet chromatographic method was developed for the simultaneous determination of Telmisartan and Amlodipine besylate by simultaneous equation method. The absorbance of wavelength for two drugs was found to be 240nm and 230nm. Linearity was established for Telmisartan and Amlodipine besylate in the range of 0-6µg/ml and 0-25µg/ml, respectively. The percentage recoveries of Telmisartan and Amlodipine besylate were found to be in the range of 100.57% and 100.35%, respectively. Both the drugs were subjected to acid, alkali and neutral hydrolysis, oxidation, dry heat, photolytic and UV degradation. This method can be successfully employed for simultaneous quantitative analysis of Telmisartan and Amlodipine besylate in bulk drugs and formulations.
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