Abstract
Pesticides commonly used in the Republic of Serbia (tebuconazole, pendimethalin, pyraclostrobin, propiconazole and famoxadone) have high stability, so their potential toxicity to humans needs to be investigated. These pesticides are in use in the Republic of Serbia in various formulations. Their toxicity and interactions with acetylcholinesterase were thoroughly investigated in this study using computational tools. The ADMET (adsorption, distribution, metabolism, excretion, toxicity) study showed that all of them are efficient oral compounds, and that pendimethalin was a mutagenic compound. Glide scores ranged from ?18.41 (pendimethalin) to ?27.61 kJ mol-1 (famoxadone) in Mus musculus, and from ?19.58 (pendimethalin) to ?24.31 kJ mol-1 (propiconazole) in Homo sapiens. In addition, the experimental stability of the pesticides solutions in methanol was studied using the fast gas chromatography?mass spectrometry (GC?MS, retention times of the studied pesticides ranged from 14.47 (pendimethalin) to 22 min (famoxadone)). They showed good stability over time, apart from pyraclostrobin which decomposed mainly into its desmethoxy derivative after 20 months. Based on the promising modelling results, pyraclostrobin and famoxadone emerge as potential candidates for further investigation in the treatment of Alzheimer?s disease, taking care to increase their stability.
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