ST2 in heart failure with reduced and mid-range ejection fraction: clinical and instrumental relationships and prognostic value

Abstract

Objectives to determine the clinical and instrumental relationships and prognostic value of sST2 in chronic heart failure with reduced and mid-range ejection fraction of ischemic etiology.
 Material and methods. The study included examination of 64 patients with heart failure with left ventricular ejection fraction 50% and myocardial infarction in medical history; mean age 55.7 8.7 years.
 Results. Higher concentrations sST2 was determined with an increased end-diastolic volume, left ventricular aneurysm, left main coronary artery stenosis, glomerular filtration rate 90 ml/min/1.73 m2 (p 0.05 for all ). The study confirmed a high predictive significance of increased levels sST2 (p = 0.001); the area under the curve was 0.772; the odds ratio for an adverse outcome with sST2 35 ng/ml was 3.93.
 Conclusion. sST2 is a predictor of adverse outcome during the first year of follow-up in patients with heart failure with reduced and mid-range ejection fraction of ischemic etiology.