Analysis of biochemical characteristics and clinical characteristics of heart failure patients with intermediate ejection fraction

Abstract

Objective To analyze the biochemical characteristics and clinical characteristics of heart failure patients with intermediate ejection fraction. Methods From June 2012 to June 2017, nine hundred and thirty patients with heart failure who were hospitalized and treated in Beijing Anzhen Hospital were selected.According to left ventricular ejection fraction(LVEF), the patients were divided into heart failure with reduced left ventricular ejection fraction group (LVEF<40%), heart failure with midrange left ventricular ejection fraction group (LVEF 40%-49%) and heart failure with preserved left ventricular ejection fraction group (LVEF ≥ 50%). The number of cases of acute heart failure and chronic stable heart failure was recorded.The general patient information (gender, age, body mass index(BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), NYHA classification) laboratory test results (Brain Brain natriuretic peptide (BNP) ) and echocardiography (left ventricular end-diastolic diameter (LVEDD), left atrium diameter (LAD), septal thickness (interventricular septum thickness, IVSD), left ventricle posterior wall thickness (LVPWT) were collected. Results The proportion of patients with acute heart failure in the midrange left ventricular ejection fraction heart failure was similar to the heart failure with reduced left ventricular ejection fraction (38.0%(35/92) vs.45.4%(210/463), P>0.05), but significantly higher than the heart failure with preserved left ventricular ejection fraction (38.0%(35/92) vs.10.4%(210/463), P=0.000). The proportion of NYHA class IV patients in the heart failure with midrange left ventricular ejection fraction was lower than the heart failure with reduced left ventricular ejection fraction(10.9%(10/92) vs.24.6%(114/463), P=0.000), and higher than the heart failure with preserved left ventricular ejection fraction (10.9(10/92) % vs.2.9%(11/375), P=0.000). Left atrial diameter, left ventricular end diastolic diameter in the heart failure with reduced left ventricular ejection fraction were maximum((47±8)mm, (67.3±9.0)mm), the heart failure with midrange left ventricular ejection fraction were medium((44±7)mm, (60.0±7.5)mm), the heart failure with preserved left ventricular ejection fraction were minimum((42±7)mm, (41.7±6.1)mm), and the difference between the three groups was statistically significant (F=44.200, F=648.426, P<0.05). Conclusion Some biochemical and echocardiographic features of heart failure with midrange left ventricular ejection fraction patients are located between heart failure with reduced left ventricular ejection fraction and heart failure with preserved left ventricular ejection fraction.The LVEDD is significantly increased in heart failure with midrange left ventricular ejection fraction and heart failure with reduced left ventricular ejection fraction group.The ventricular remodeling in heart failure with midrange left ventricular ejection fraction is similar to that of heart failure with reduced left ventricular ejection fraction. Key words: Ejection fraction; Heart failure; Clinical characteristics