Abstract
In the present study, sol–gel derived BGs based on 60% SiO2-(36-x) CaO-4P2O5-x SrO (where x = 2, 4, 6 and 8 mol%) system were synthesized. The effect of Sr on bioactivity and proliferation of G292 cells was investigated. X-ray diffraction analysis (XRD), Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were utilized to study the obtained phases, HA morphology, and its functional groups, respectively. The XRD and FTIR tests showed that the rate of hydroxyapatite formation on sample 2S was higher than that of other samples. The 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay after one day immersion in SBF, showed that the viability of the samples containing 6 mol% Sr (6S) increases by increasing immersion time, while the sample containing 8 mol% Sr (8S) showed a decrease in bioactivity in osteoblast G292 cells proliferation. According to the results 6S BG specimen with 6 mol% SrO exhibited appropriate bioactivity and cell proliferation.
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