Spread through air spaces in non-small cell lung cancer: Experience of a tertiary hospital.

Abstract

e20606 Background: Tumor spread through air space (STAS) is a novel pattern of invasion related to poor prognosis in non-small cell cancer (NSCLC). In 2015, Kyuichi Kadota first described spread through air spaces (STAS) as a novel histologic pattern of invasion related to poor prognosis NSCLC. The objective of this study is to describe the incidence of STAS in a surgical series of NSCLC patients resected in Hospital Universitario Puerta de Hierro-Majadahonda and identify the association of STAS with clinicopathological characteristics. Methods: Observational retrospective cohort study was performed from 2015 to 2021. Inclusion criteria were: age more than 18 years, histologically confirmed diagnosis of NSCLC, clinical stage I-IV and radical treatment with surgery. Descriptive analysis was performed. Results: 178 patients were included. 69.1% (123) were male, median age was 68.0 years. In relation to histological subtypes: 65.2% were adenocarcinoma, 22.5% squamous-cell carcinoma and 12.3% other histologies. Patients were classified by pathological stage: 71.9% were in stage I, 11.4% in stage II, 15.6% in stage III and 1.1% in stage IV. STAS was observed in the surgical specimen in 62 cases (34.8%). In Table-1 the association of STAS with clinicopathological characteristics is shown. Conclusions: In our study, we found statistically significant association between STAS and histological subtype and presence of lympho-vascular invasion. STAS were present more frequently in adenocarcinoma and were associated with more incidence of lympho-vascular invasion, as reported in other studies. More analysis are required for further description of this dissemination pattern and its implication in the prognosis of the patients. [Table: see text]