Comment on: 'Correlation of Tumor Spread through Air Spaces and Clinicopathological Characteristics in Surgically Resected Lung Adenocarcinomas'

Abstract

We read with great interest the study by Szu-Yen Hu et al. [ [1] Hu S.Y. Hsieh M.S. Hsu H.H. et al. Correlation of tumor spread through air spaces and clinicopathological characteristics in surgically resected lung adenocarcinomas. Lung Cancer. 2018; 126: 189-193 Abstract Full Text Full Text PDF PubMed Scopus (34) Google Scholar ].This retrospective study identified that the presence of spread through air spaces (STAS) might be considered as a staging profile of lung adenocarcinomas in future staging system, because STAS was significantly correlated with several invasive clinicopathological characteristics (e.g., higher T, N stages, moderate/poor differentiation and the presence of lymphovascular invasion) in multivariate analysis for resected lung adenocarcinoma. Herein, we would like to raise the following comments: Correlation of tumor spread through air spaces and clinicopathological characteristics in surgically resected lung adenocarcinomasLung CancerVol. 126PreviewThe current standard for non–small cell lung cancer (NSCLC) pathological TNM staging is based on the American Joint Committee on Cancer (AJCC) Cancer Staging Manual, 8th edition [1]. The pathological prognostic factors incorporated in the 8th TNM staging system are histological non-invasive subtype and visceral pleural invasion. Other clinicopathological characteristics, such as lymphovascular invasion, elevated serum carcinoembryonic antigen (CEA) level, and tumor differentiation, were also proven to be correlated with survival in NSCLCs [2,3]. Full-Text PDF Response to comment on: “Correlation of Tumor Spread through Air Spaces and Clinicopathological Characteristics in Surgically Resected Lung Adenocarcinomas.”Lung CancerVol. 132PreviewWe appreciate the interest and comments for our article, titled “Correlation of Tumor Spread through Air Spaces and Clinicopathological Characteristics in Surgically Resected Lung Adenocarcinomas [1]”. Full-Text PDF