Abstract
the ST1-MRSA-IV Australian isolates is encoded on an 2 kb plasmid, pWBG738, which has now been completely sequenced (accession number NC_007209). Interestingly, pWBG738 (2473 bp) has 99% nucleotide identity with pT48 (2475 bp) (accession number NC_001395) which was harboured by a strain of S. aureus isolated from an infected patient in Florida, USA. pWBG738 encodes the erm(C) MLS-resistance gene whose product is the ErmC methylase that mediates resistance by dimethylation of an adenine residue in 23S rRNA. The erm(C) control region of pWBG738, containing the leader peptide and secondary structures that mediate control by translational attenuation, is functionally intact. As deletions in the erm(C) control region result in the constitutive MLS phenotype, we urge caution in the use of macrolide, lincosamide and streptogramin B antibiotics, such as clindamycin, to treat CMRSA infections.
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