Abstract
Spontaneous regression of a malignant tumor is extremely rare. Here we report two cases of spontaneous regression of hepatocellular carcinoma (HCC), and review the associated literature. Case 1 was a 77-year-old male with HCC in the right lobe and multiple lung metastases. alpha-fetoprotein (AFP) and protein induced by vitamin K deficiency or antagonist II (PIVKA-II) were >50,000ng/ml and 21,500mAU/ml, respectively. He and his family refused further treatment, and he was discharged. Four months after the diagnosis, dramatic diminution of HCC and lung metastases was noted, and the HCC had disappeared completely 12 months later. Case 2 was a 72-year-old male with multiple nodular regions with enhanced circumference in the right lobe, the largest of which was 8cm in diameter, referred to the gastroenterology unit of our hospital. Laboratory analyses showed positive for hepatitis C virus antibody, and AFP and PIVKA-II were 936.3ng/ml and 2,380mAU/ml, respectively. However, he and his family refused further treatment, and he was followed-up as an outpatient by a local clinic. Two years later, radiological investigations revealed remarkable regression of HCC. Laboratory analyses showed that PIVKA-II had decreased to the normal range, while AFP had increased to double the original value.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Hepatology research : the official journal of the Japan Society of Hepatology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.