Abstract
Summary A spontaneous focal fragmentation of the elastin in the dog carotid artery is described. The lesion is characterized by perielastic metachromasia, smooth muscle degeneration, infiltration of fibroblastlike cells around the elastic plates, and collagen deposition. The internal elastic membrane becomes segmented, stains with toluidine blue, and fails to stain with orcein. Areas of the lesion accumulate collagen and in what is believed to be an advanced stage demonstrate a densely collagenized plaque which may protrude into the vascular lumen. Since the incidence of the lesion was not restricted to the older animals, it may be related to arteriosclerosis or to some transitory reconstructive phase in the growth of arteries.
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