Sponge proteins are more similar to those of Homo sapiens than to Caenorhabditis elegans

Abstract

We compared 42 phylogenetically conserved proteins from four marine sponges [Porifera] with almost the complete set of Caenorhabditis elegans proteins and all known proteins from humans. The majority of the sponge proteins arc significantly more similar to human than to C. elegans orthologucs/homologues. This finding reflects the accelerated evolutionary rate in the C. elegans lineage, since sponges split off first from the common ancestor of all multicellular animals. Furthermore, three sponge/human proteins were not found in C. elegans: (2–5)A synthetase, DNA repair helicase and lens βγ-crystallin. Sponges arc the source of the most ancient proteins already present in the common ancestor of all multicellular organisms. Some of these proteins were lost later during the evolution of individual animal lineages. These ‘found/lost’ proteins may serve as molecular markers for an improved systematics of Metazoa. In addition, phylogenetically conserved sponge proteins can be very helpful for the evaluation of differences in evolutionary rates in different animal lineages. We therefore propose sponges as the reference animals in molecular evolutionary studies of Metazoa.