Abstract
Lymphocyte Homing Lymphocytes are immune cells that travel through the body, alternating between periods of residence in lymphoid organs and periods of circulation in blood and lymphatic vessels. Tadayon et al. investigated where circulating lymphocytes first exit the vasculature of the mouse spleen to gain access to the lymphocyte-rich splenic white pulp. Minutes after adoptive transfer of labeled lymphocytes, the majority were found in the red pulp zone of the spleen. The Clever-1 adhesion and scavenger receptor on endothelial cells was an important facilitator of initial entry of B cells and CD8+ T cells into the red pulp. Distinct molecular mechanisms apparently govern how lymphocytes traffic into the spleen compared with the lymph nodes. Sci. Immunol. 4 , eaat0297 (2019).
Published Version
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