Abstract
In a group of 34 children (ages 6 mos.-20 yrs.)who were splenectomizod due to trauma(15 cases) and non-trauma(19 cases of ITP, beta thalassemia, hereditary spherocytosis, portal hypertension, hyperslenism), the absolute lymphocyte counts, E rosettes, skin tests(PHi, candida,SKSD,PPD), isohemagglutinins and serum IgG levels were not different than those of 34 age matched controls (P > 0.05). However serum IgA and IgM levels were low (P < 0.05 ). Fifteen patients(44%) developed infections(bronchopneumonia, hepatitis, wound abscess, sepsis)following splenectomy. A defective opsonization for pneumococcus type II-L was found in 8. Six of these had various infections. Pre and post splenectomy immunoglobulins determined in 11 cases showed low IgA and IgM levels in 8 and 9 patients respectively. Our study also confirms the high incidence of infection regardless of the cause for splenoctomy since 33-3% of the patients in traumatic and 52.6% of the patients in non-traumatic group had infection.
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