Abstract

RationaleAllergic diseases result in recurrent respiratory symptoms. On the other hand, impaired humoral immune response may be a cause of recurrent respiratory symptoms/infections.Preschool children are prone to recurrent respiratory infections. In this study, we investigated the presence of hypogammaglobulinemia in preschool children with allergic disease and recurrent respiratory infections.Methods62 children (0-5 years) who admitted to the Pediatric Allergy Immunology Department between 2009 and 2014 with the allergic complaints were included to the study. The presence of atopy were confirmed with skin prick test positivity, positive spesific IgE levels and high total IgE levels. Serum IgG, IgA, IgM and total IgE levels were measured and evaluated based on age.Results23 of the patients were girls and 39 of them were boys. Mean age was 34.7±17.6 months. Totally 15 patients had hypogammaglobulinemia. 8 of them (12.9 %) had low IgG levels, four of them (6.5%) had low IgM levels and 10 patients (16.1%) had low IgA levels. Among the patients who have hypogammaglobulinemia (8 children), three children have food allergy, three children have urticaria, one child has got asthma, one child has got allergic rhinitis. Among the patients who have low IgM levels (four children), two of them have urticaria, one child has got food allergy and one child has got asthma. Five children who have low IgA levels have food allergy, three of them have urticaria an done of the has got asthma.ConclusionsThe allergic preschool children with recurrent respiratory infection should be screened for hypogammaglobulinemia. RationaleAllergic diseases result in recurrent respiratory symptoms. On the other hand, impaired humoral immune response may be a cause of recurrent respiratory symptoms/infections.Preschool children are prone to recurrent respiratory infections. In this study, we investigated the presence of hypogammaglobulinemia in preschool children with allergic disease and recurrent respiratory infections. Allergic diseases result in recurrent respiratory symptoms. On the other hand, impaired humoral immune response may be a cause of recurrent respiratory symptoms/infections. Preschool children are prone to recurrent respiratory infections. In this study, we investigated the presence of hypogammaglobulinemia in preschool children with allergic disease and recurrent respiratory infections. Methods62 children (0-5 years) who admitted to the Pediatric Allergy Immunology Department between 2009 and 2014 with the allergic complaints were included to the study. The presence of atopy were confirmed with skin prick test positivity, positive spesific IgE levels and high total IgE levels. Serum IgG, IgA, IgM and total IgE levels were measured and evaluated based on age. 62 children (0-5 years) who admitted to the Pediatric Allergy Immunology Department between 2009 and 2014 with the allergic complaints were included to the study. The presence of atopy were confirmed with skin prick test positivity, positive spesific IgE levels and high total IgE levels. Serum IgG, IgA, IgM and total IgE levels were measured and evaluated based on age. Results23 of the patients were girls and 39 of them were boys. Mean age was 34.7±17.6 months. Totally 15 patients had hypogammaglobulinemia. 8 of them (12.9 %) had low IgG levels, four of them (6.5%) had low IgM levels and 10 patients (16.1%) had low IgA levels. Among the patients who have hypogammaglobulinemia (8 children), three children have food allergy, three children have urticaria, one child has got asthma, one child has got allergic rhinitis. Among the patients who have low IgM levels (four children), two of them have urticaria, one child has got food allergy and one child has got asthma. Five children who have low IgA levels have food allergy, three of them have urticaria an done of the has got asthma. 23 of the patients were girls and 39 of them were boys. Mean age was 34.7±17.6 months. Totally 15 patients had hypogammaglobulinemia. 8 of them (12.9 %) had low IgG levels, four of them (6.5%) had low IgM levels and 10 patients (16.1%) had low IgA levels. Among the patients who have hypogammaglobulinemia (8 children), three children have food allergy, three children have urticaria, one child has got asthma, one child has got allergic rhinitis. Among the patients who have low IgM levels (four children), two of them have urticaria, one child has got food allergy and one child has got asthma. Five children who have low IgA levels have food allergy, three of them have urticaria an done of the has got asthma. ConclusionsThe allergic preschool children with recurrent respiratory infection should be screened for hypogammaglobulinemia. The allergic preschool children with recurrent respiratory infection should be screened for hypogammaglobulinemia.

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