Abstract
Background: Diabetes mellitus is a non-communicable disease of global health importance. It is a metabolic disorder caused by increased levels of blood glucose over a prolonged period of time. Type 2 diabetes mellitus (T2DM) is usually associated with obesity and insulin resistance. Several studies have also revealed that diabetes mellitus hampers pulmonary functions. This study was aimed at estimating the spirometric indices in type 2 diabetes mellitus patients.
 Methods: A cross-sectional study of T2DM patients and apparently healthy control attending the medical outpatient clinic in a tertiary institution in south western Nigeria.
 Results: A total of 146 participants with 73 patients with T2DM and 73 control groups. There were no significant differences in the age, body mass index, and gender distribution of the diabetics and control. However, patients with diabetes had higher SBP (133.2±20.17 mmHg vs 111.6±6.5 mmHg p<0.0001), and DBP (78.4±11.8mmHg vs 73.7±6.3 mmHg, p=0.003) when compared to the control. The mean FEV (1.98±0.5 vs 2.09±1.2, p=0.033), FVC (2.35±0.6 vs 2.53±1.3, p=0.045) and FEV/FVC ratio (83.61±7.2 vs 81.14±10.7, p=0.029) were significantly lower in diabetic patients when compared to matched controls. There was no significant difference in the PEF and FEF of both groups.
 Conclusion: Type 2 diabetes mellitus patients had significant decrease in their spirometric indices, hence pulmonary function should be included in the periodic comprehensive diabetic check for holistic management.
Highlights
Diabetes mellitus is a metabolic non-communicable disease, one of the most serious public health challenges worldwide [1], [2]
Diabetes mellitus is one of the non-communicable diseases (NCD) with global rising burden and it is associated with various microvascular and macrovascular complications which contribute to increased morbidity and mortality [4]
There is a global rise in the incidence of Type 2 diabetes mellitus (T2DM) with 80% of people with DM living in low- and middle-income countries and an observed increase in the burden in the African population [2], [6]
Summary
Diabetes mellitus is a metabolic non-communicable disease, one of the most serious public health challenges worldwide [1], [2]. Diabetes mellitus is one of the non-communicable diseases (NCD) with global rising burden and it is associated with various microvascular and macrovascular complications which contribute to increased morbidity and mortality [4]. Studies have shown impaired lung function among patients with diabetes mellitus [14]-[17]. Diabetes mellitus is a non-communicable disease of global health importance. It is a metabolic disorder caused by increased levels of blood glucose over a prolonged period of time. This study was aimed at estimating the spirometric indices in type 2 diabetes mellitus patients
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