Abstract

The shape-persistent bicyclic nortropane fragment is frequently found in both natural remedies and synthetic drugs. Herein we review synthetic approaches towards spirocyclic nortropanes, as well as their studied stereochemical properties and biological activity. 1 Introduction 2 Spiro-hybrids of nortropane with three-membered cycles 3 Spiro-hybrids of nortropane with four-membered cycles 4 Spiro-hybrids of nortropane with five-membered cycles 5 Spiro-hybrids of nortropane with six-membered and larger cycles 6 Conclusion

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