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https://doi.org/10.1016/j.bmcl.2018.06.019
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Cite Publication Date: Jun 12, 2018 | |
 Citations: 12 |
Here we report the design and synthesis of spiro[pyrrolidine-3,3′-oxindole] derivatives representing a novel scaffold of 5-HT7 receptor ligands. The synthesized analogues were validated as low nanomolar ligands showing selectivity in a panel of related serotonin receptor subtypes including 5-HT1AR, 5-HT2AR and 5-HT6R.
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