Abstract
Two isoforms of sphingosine kinase (SK) catalyze the phosphorylation of sphingosine (Sph) to sphingosine-1-phosphate (S1P). SK1 is involved in many key processes in the cell, such as proliferation, cell survival and migration. There is also evidence that calcium entry through store-operated calcium (SOC) channels is involved in regulating proliferation and migration. The substrate for SK1, Sph, blocks the calcium-release activated current, which is the electrophysiological counterpart to store-operated calcium entry (SOCE). The purpose of the present study was to investigate the possible involvement of SK1 in receptor-operated calcium entry (ROCE) and SOCE, and if this can be linked to the migration of HeLa cells.
Published Version
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