Abstract
Sperm cell membranes contain many lipids that are essential to its structure and function. These lipids include Very Long Chain PUFA (VLC-PUFA ≥ 28 carbons). Prior studies in animal models have suggested that VLC-PUFAs are important for normal fertility.We have previously demonstrated a significant positive correlation between VLC-PUFA and sperm concentration in 70 infertile men undergoing treatment. We hypothesized that the sperm VLC-PUFA-containingsphingolipid concentration is correlated not only with sperm parameters, but also with the outcome of live birth following conventional therapy for unexplained and mild male factor infertility.
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