Abstract
Abstract In the paper, we describe and develop more effective solutions of two important problems in bioinformatics. The first problem is the multiple sequence alignment problem and the second problem is RNA secondary structure prediction (folding) problem. Each of these problems should be solved with better results if we know the solution of the other one, but usually we only have sequences and we know neither the alignment nor the secondary structure. Precise algorithms solving both of these problems simultaneously are computationally pretentious according to the big length of RNA sequences. In this paper, we have described the method of speeding up the Sankoff’s simultaneous alignment and folding algorithm using the Carrillo-Lipman approach to cut off those computations, that can never lead to an optimal solution.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call