Spectrum of histopathological changes in fibroadenoma of breast

Abstract

Introduction: Fibroadenoma commonly known, as ‘Breast Mouse’ is freely mobile, benign tumour of the breast. It is composed of epithelial and stromal components. These components may show varied histomorphological changes. The aim of the present study is to explore the histopathological features of the epithelium and stroma within and around breast fibroadenoma. Materials and Methods: This is a retrospective and prospective unicentre study on total 317 cases of fibroadenoma over a period of two years. Formalin fixed specimens were grossed and stained with routine H&E. Further detailed histopathological examination was done. Results: Simple features were noted in 94% whereas 6% showed complex features. On detailed HPE, proliferative epithelial changes like mild ductal hyperplasia was seen in 73.5% of cases followed by moderate ductal hyperplasia seen in 12.6%. Among the fibrocystic epithelial changes apocrine metaplasia, cystic changes and calcification were observed in 35.91%, 18.3% and 5% cases respectively. Only 71 cases had adjacent parenchyma revealing insignificant changes. Increasing age had statistically significant relationship with complex features. This is statistically significant with p value < 0> Conclusion: Histopathological Examination of fibroadenomas should be done thoroughly to see atypical, complex changes or any malignant feature. Further follow up should be recommended in cases with proliferative changes for early detection of malignancy. Keywords: Fibroadenoma, Histopathological changes, Malignant transformation.