Abstract
Recently, alkyl resorcinol compounds showed remarkable improvements on dental implant restoration as well as anaesthetic, antiseptic, and anthelmintic applications. In this study, we prepared biologically functional composition of 4-hexylresorcinol (4HR)-loaded hydroxyapatite (HA). Attenuated total reflectance (ATR) Fourier-transform infrared (FT-IR) spectroscopy fully assigned vibrational absorptions of 4-hexylresorcinol as well as the HA. The absorption coefficient of 4HR aqueous solution is estimated to be 1393 ± 61 cm−1 M−1 at highly diluted concentration. The 4HR was loaded with 0.018 % (wt/wt) in the 4HR-HA composite. We quantitatively determined the micromolar concentration of 4HR loaded in the composite based on ultraviolet-visible (UV-Vis) absorption spectroscopy.
Highlights
Alkyl resorcinol compounds showed remarkable improvements on dental implant restoration as well as anaesthetic, antiseptic, and anthelmintic applications
We quantitatively determined the micromolar concentration of 4HR loaded in the composite based on ultraviolet-visible (UV-Vis) absorption spectroscopy
Infinitesimal amount of 4HR, which was loaded on HA powder, could be detected and precisely estimated based on UV-Vis absorption spectroscopy
Summary
Hydroxyapatite (HA) is the major component of bone material and a hexagonally packed crystal with hydroxyl end members (Pleshko et al 1991). Infection-resistant HA coating with bioinert antiseptic function is of great interest. A 4-hexylresorcinol (4HR)-treated HA-titanium dental implant showed significant improvement in both. Hexylresorcinol have been used in a variety of application areas, such as skincare products with anti-aging function, food additive with estrogenic activity (Amadasi et al 2009), and anti-cancer activity by inhibiting NF-κB (Kim et al 2011a). Yang et al Journal of Analytical Science and Technology (2016) 7:9 composite materials with a demanded function (Kweon et al 2014; Lee et al 2015). Solution-processed 4HR-loaded HA composite were quantitatively characterized using Fourier-transform infrared (FT-IR) and ultraviolet-visible (UV-Vis) absorption spectroscopies. Infinitesimal amount of 4HR, which was loaded on HA powder, could be detected and precisely estimated based on UV-Vis absorption spectroscopy. We entirely assigned IR absorption peaks of 4HR for the first time
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