Abstract

A four step synthetic approach afforded N-benzyl-1H-indole-3-carboxamide in a moderate yield. The process involved formylation with Vismeier-Haack reagents, followed by disproportionation through the Cannizzaro reaction, chlorination using thionyl chloride, and subsequent substitution with benzylamine, ultimately generating the target compound. The compound was analysed using, 1H NMR (Proton nuclear magnetic resonance), 13C NMR (carbon nuclear magnetic resonance) and FTIR (fourier transform infrared) spectrophotometry. The FT-IR spectrum of the compound show characteristics peaks at 1540 cm-1 for C=C of benzene ring, at 1660 cm-1 for C=O of amide, sp3 C-H stretching frequency, that is, the methylene bonded to the nitrogen of the amide at 2900 cm-1, N-H. The proton and carbon data were obtained using the aforementioned nuclear magnetic resonance spectrometers, and the corresponding spectrum displaced chemical shifts that align with the proposed structure of the target molecule.

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