Abstract
Interaction of M(II) ions, M=Co, Ni, Cu, Zn, and Pd, with a Schiff base ligand (HL), derived from the condensation of 2-hydroxy-5-nitrobenzaldehyde and 8-aminoquinoline, gave the complexes [Co(L)2(H2O)2], [Ni(L)2(H2O)2], [Cu(L)(H2O)]CH3COO, [Zn(L)(H2O)]CH3COO, and [Pd(HL)Cl2]. The ligand and its complexes were characterized by means of elemental and thermal analyses, molar conductance, and magnetic moment measurements along with the different spectroscopic techniques. Theoretical calculations based on DFT were carried out to verify the optimized structures of ligand and complexes. The relative reactivity of the compounds was estimated from chemical descriptors analysis using the HOMO and LUMO frontier orbitals. Molecular docking of ligand and its zinc complex revealed that the interaction of Zn(L) with DNA is comparable to that of HL due to the presence of water OH groups instead of the hydroxyl group of ligand.
Highlights
In the last few decades, Schiff base derivatives showed a vital importance in the chemistry of organic and coordination compounds [1, 2, 3, 4]
The chloro-aminoquinoline Schiff base derivatives were screened for their anticholinesterase activity, which assessed for Alzheimer disease [17]
On continuation of our interest in synthesis and investigations of many Schiff base ligands and their transition metal complexes [2, 4, 21, 22, 23], here we report the synthesis of a Schiff base derived from the condensation of 2-hydroy-5-nitro benzaldehyde and 8-aminoquinoline as well as its Co(II), Ni(II), Cu(II), Zn(II), and Pd(II) complexes
Summary
In the last few decades, Schiff base derivatives showed a vital importance in the chemistry of organic and coordination compounds [1, 2, 3, 4]. They are found to be valuable in optical computers to measure and control of the radiation of imaging systems, in the molecular memory storages and photo detectors in biological systems [10]. Many studies of mixed ligand complexes with nitrogen-containing heterocyclic derivatives (such as 8-hydroxyquinoline and 2-aminothiazole) and the corresponding Schiff base ligands were reported. These derivatives have interesting structural features and in vitro antimicrobial and cytotoxicity activities [18]. Biological activities along with DFT calculations and molecular docking were used to characterize the ligand and the complexes
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