Abstract
The ion-associate complexes of diaveridine were prepared in a solution and studied spectrophotometrically. The bulky counter anions such as sulfonphthalein acidic dyes, namely, bromocresol green (I), bromophenol blue (II), bromothymol blue (III), bromocresol purple (IV), bromocresol blue (V), o-cresol red (VI), p-cresol blue (VII), and m-cresol purple (VIII) were used for ion-associate complexes formation. The optimal characteristics for the color formation and the stoichiometry of the reaction were evaluated. Spectral characteristics and stability constants of the formed ion associates are discussed in terms of nature of donor and acceptor molecular structures. The molar absorptivities and association constants for the colored complexes were evaluated using the Benesi-Hildbrand equation. Conformity to Beer’s law enabled the assay of dosage form of the drug. The molar absorptivity, specific absorptivity, Sandell sensitivity, correlation coefficient, and detection and quantification limits were also calculated. The methods were validated in terms of accuracy, specificity, precision, and linearity. Also, spectrophotometric determination of the drug in pure and pharmaceutical preparations was tested.
Highlights
Compounds containing pyrimidine rings play a significant role in many biological systems due to their coordinating properties
We aim to study the reaction of this drug with bulky counter anions such as sulfonphthalein acidic dyes
Sulfonphthaleins are one of the most interesting families of anionic dyes and have attracted scientific attention; this is attributed to their molecular structure which allows formation of ion-associate complexes with various drugs, where ion pair or ion association complexes are those complexes in which the analytical species associates with oppositely charged ions to form neutral compounds [9,10,11,12]
Summary
Compounds containing pyrimidine rings play a significant role in many biological systems due to their coordinating properties. E analysis of diaveridine in New-Cox is performed by weighting (0.0573 g) New-Cox drug corresponding to 1.0 × 10−3 mol/L, dissolving it in 1 mL of absolute ethanol, after that diluting it to 100 mL with the suitable solvent Different aliquots of this solution were subjected to analysis as reported. Sulfonphthalein dyes have in their general molecular structure, shown in Scheme 1, different substituents so they may affect the dissociation of the reagent and the formation of the ion-associate complexes. The color of dyestuff is due to the opening of lactoid ring and subsequent formation of the quinoid group as represented in Scheme 2, and anionic dyes of the sulfonphthalein group present mainly in anionic form; this facilitates the formation of ion-associates complexes. E possible reaction mechanisms are given in Scheme 3. e parameters that affect the formation of ion-associate complexes such as selection of suitable wavelength, effect of reagent concentration, effect of sequence of addition, effect of solvents, effect of time, effect of temperature, and effect of interference were studied
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