Abstract
Two simple, rapid, sensitive and accurate spectrophotometric methods have been developed for the estimation of metronidazole. The method depends on the reduction of Metronidazole molecule with zinc powder and hydrochloric acid followed by diazotization and coupling with 2-hydroxybenzaldehyde to give yellow colored in alkaline medium with an absorption maximum at 457 nm. Under optimized experimental conditions Beer's law was obeyed in the concentration ranges 3.0 to 15.0 μg/ml and 25.0 to 37.0 μg/ml. Also, by using p-aminoacetophenone as a coupling agent to form orange colored with an absorption maximum at 490 nm. Beer's law was obeyed in the concentration ranges 3.0 to 40.0 μg/ml. The Sandell's sensitivity, the molar absorptivity, correlation coefficient, detection limit and the regression equation were calculated. Both techniques were applied successfully to a wide variety of pharmaceutical preparations
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