Abstract
This paper describes a sensitive spectrophotometric method developed for determination of Ketoconazole (KC) in tablets based on amplification reactions. Ketoconazole was oxidized with periodate, resulting in formation of KC2+ and iodate ions. After masking the excess periodate with molybdate, the iodate was treated with iodide to release iodine. The liberated iodine was transformed to ICl2− species and extracted as ion-pair with rhodamine 6G into toluene for spectrophotometric measurement at 535nm. A linear calibration graph was obtained between 0.2136μg/mL and 1.7088μg/mL of Ketoconazole with a molar absorptivity of 5×105mol·L−1cm−1. The procedure was successfully applied for the determination of ketoconazole in tablet formulation.
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