Abstract
New simple, sensitive, rapid, reproducible and economical spectrophotometric method have been developed for the determination of amoxicillin trihydrate in pharmaceutical bulk and tablet dosage form using citro phosphate buffer pH 7.2. The system obeys Lambert‐Beer′s law at 231 nm in the concentration range 2.5‐50 μg/m. Molar absorptivity, correlation coefficient and Sandell′s sensitivity values were found to be 1.0020 x 104 mol-1 cm, -1 0.9996 and 0.03906 μg cm-2 respectively. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate
Highlights
Amoxicillin trihydrate is chemically (2S, 5R, 6R)-6-[(R)-(-)-2-amino-2-(p-hydroxy phenyl) acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
In the present investigation we have developed simple, sensitive and reproducible spectrophotometric method for the determination of amoxicillin trihydrate
Amoxicillin trihydrate used in the present investigation is obtained from Tini Pharma Ltd, Renigunta, Tirupati
Summary
Amoxicillin trihydrate is chemically (2S, 5R, 6R)-6-[(R)-(-)-2-amino-2-(p-hydroxy phenyl) acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate. The official methods of the estimation are calorimetry[4] and microbilogical[5]. Other methods of its estimation including titrimetry[6], polarography[7], folrimetry[8,9,10,11], HPLC12, calorimetry[13,14,15,16,17,18,19,20] and spectrophotometry[21,22,23,24]. In the present investigation we have developed simple, sensitive and reproducible spectrophotometric method for the determination of amoxicillin trihydrate.
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