Abstract
In this work, determination of naproxen concentration by chitosan capped silver nanoparticles were investigated. A new, simple and inexpensive spectrophotometric method for the first time was developed. The characteristics of chitosan capped silver nanoparticles were determined by ultraviolet spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), atomic force microscopy (AFM), dynamic light scattering (DLS) and zeta potential (ZP) under optimal conditions. It worth to be mentioned that, synthesized chitosan (CS) -Ag nanoparticles were approximately 100 nm and PDI 0.385 with strong anionic (-24.8mV) zeta potential in acidic condition. It was found that chitosan as a chiral selector was able to detect naproxen at optimal experimental conditions. Validation of this method, including limit of detection and limit of quantification were accurately confirmed according to ICH instructions. Based on this method, the limit of detection (LOD) and the limit of quantification (LOQ) of naproxen were calculated 0.022 and 0.066 mol. L-1, respectively. Analysis of statistical data, the reproducibility and accuracy of this method demonstrated that the use of this novel method is valuable and practical for determination of naproxen in pharmaceutical formulations
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
