Abstract
A fast, cheap, and straightforward spectrophotometric method has been proposed to determine meloxicam (MEL) in its pure form and pharmaceutical formulation. The technique involves diazotizing the (NH2) group in 4-nitroaniline with NaNO2 followed by a reaction with meloxicam to produce a stable and colored complex in a basic medium. This complex demonstrates maximum absorbance at 514 nm. The developed method's linearity ranges from 2.0 - 25 μg mL-1, and the molar absorptivity is 1.5989×104 L mol-1 cm-1. The RSD% is lower than 1.55%. Additionally, the limit of detection (LOD) is 0.2019 μg mL-1. The method successfully determines the pharmaceutical preparation containing meloxicam (Loxim tablets) with a recovery rate of no less than 97.9%.
Published Version
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