Spectrophotometric determination of mebeverine hydrochloride

Abstract

Three simple, sensitive and reproducible visible spectrophotometric methods (A-C) for the determination of mebeverine hydrochloride (MVH) in bulk samples and pharmaceutical formulations are described. Methods A and B are based on the formation of ion-association complexes between the drug and fast green FCF (FGFCF, λmax 625 nm) or bromothymol blue (BTB, λmax 405 nm). Method C is based on the formation of a molecular complex between the drug and cobalt thiocyanate (CTC, λmax 625 nm). Regression analysis of Beer's plots showed good correlation in the concentration ranges 2–40, 2–25 and 100–600 μg/ml for methods A, B and C respectively. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the methods was examined by analysing tablets containing MVH. Standard deviations were typically ⩽ 0.75 mg per dose (RSD: 0.25–0.5%). Recoveries were 99.0–100.2%.