Abstract
Out of 7 pharmaceutical secondary aromatic amines tested, the oxidative coupling reaction of 3-methyl-benzothiazolin-2-one hydrazone with aromatic amines in the presence of iron (III) ammonium sulphate was applied to the determination of folic acid, primaquine phosphate and lucanthone hydrochloride. The wavelengths of maximum absorption were 530 nm (for primaquine phosphate), 580 nm (for lucanthone hydrochloride) and 660 nm (for folic acid) with molar absorptivities of 4.6 x 104, 2.3 x104 and 5.0 x 104 respectively. Beer's law was obeyed in the concentration range of 2-10 mg ml-1 (for primaquine phosphate), 2-16mg ml-1 (for lucanthone hydrochloride) and 1-10mg ml-1 (for folic acid). The proposed method was applied for the quantitative of folic acid, primaquine phosphate and licanthone hydrochloride in pure form as well as in tablets. Results of analyses were compared with the B.P. and U.S.P. procedures.
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