Abstract
Series of ortho, meta and para methyl substituted benzylamine (BLs) supported Pt(IV) complexes were synthesized via oxidative halogenation and characterized with FTIR, UV/Vis, LC-MS, 1H, 13C and 195Pt NMR. The UV–Vis study in DMSO, DMSO+H2O and DMSO+phosphate buffer (pH=7.2) solutions has predicted their structural sustainability in variable medium. Their structural potential supporting DNA binding activities were studied with spectrophotometric and physicochemical methods. Especially, CT-DNA interaction with complexes were determined by calculating their binding constant (Kb) due to disruption of DNA base pairs (DNABP) facilitating an intercalation, obtained from their surface tension and viscosity respectively. Their % Binding activity, % DNABP disruption and % Intercalating strength were calculated from in vitro drug-DNA interaction. The drug-DNA interaction facilitated their anticancer activity analysis as GI50<10 with 50% reduction in cancer cell counts against MCF-7 and MDA-MB-231 breast cancer cell lines. Their antioxidant activity ≥50% was observed using DPPH free radicals as compared to ascorbic acid.
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