Abstract
BackgroundCertain antidepressant drugs namely Sertraline hydrochloride, Fluoxetine hydrochloride, Paroxetine hydrochloride, Thioridazine hydrochloride and Amineptine hydrochloride were studied throughout this work using spectrofluorimetric method.MethodsThe spectrofluorimetric method is based on the charge-transfer reaction of these drugs as n-electron donors with 7,7,8,8-tetracyanoquinodimethane (TCNQ) as π-electron acceptor. The drug-TCNQ complexes showed excitation maxima ranged from 290-301 nm and emission maxima ranged from 443-460 nm.Results and discussionThe different experimental parameters affecting the formation and stability of the complexes were carefully studied and optimized. The calibration plots were constructed over the range of 50-450 ng mL-1 for Fluoxetine and Sertraline, 50-550 ng mL-1 for Paroxetine, 50-650 ng mL-1 for Thioridazine and 50-750 ng mL-1 for Amineptine. The proposed method was validated according to ICH and USP guidelines with respect to specificity, linearity, accuracy, precision and robustness.ConclusionA simple, reliable, sensitive and selective spectrofluorimetric method has been developed for determination of certain antidepressant. The proposed method was successfully applied to the analysis of the cited drugs in dosage forms. The high sensitivity of the proposed method allows determination of investigated drugs in spiked and real human plasma.
Highlights
Certain antidepressant drugs namely Sertraline hydrochloride, Fluoxetine hydrochloride, Paroxetine hydrochloride, Thioridazine hydrochloride and Amineptine hydrochloride were studied throughout this work using spectrofluorimetric method
A simple, reliable, sensitive and selective spectrofluorimetric method has been developed for determination of certain antidepressant
The proposed method was successfully applied to the analysis of the cited drugs in dosage forms
Summary
Certain antidepressant drugs namely Sertraline hydrochloride, Fluoxetine hydrochloride, Paroxetine hydrochloride, Thioridazine hydrochloride and Amineptine hydrochloride were studied throughout this work using spectrofluorimetric method. Antidepressant medications have been used to treat all forms of major depressive disorders (Parfitt & Martindale 2002). Sertraline, paroxetine, fluoxetine and amineptine are extensively used as antidepressant drugs in Egypt while thioridazine is a potent antipsychotic agent which is used in treatment of depression accompanied with anxiety. The chemical structures of the studied drugs in this work. The wide use of these drugs necessitates the development of simple, accurate, sensitive, applicable and cheaper method for their determination in pure forms, pharmaceutical formulations, spiked and real Name Chemical name. Fluoxetine Hydrochloride (3RS)-N-methyl-3-phenyl-3-[4-(trifluoromethyl) phenoxy] propane-1-amine hydrochloride Structure Cl Cl H N F NH HCl CH3
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