Abstract
Improvements in MR hardware and software allow acquisition of data at very high spectral and spatial resolution so that the details of the water and fat lineshapes in each small image voxel can be resolved (1). Data obtained with high spectral and spatial resolution (HiSS) MR imaging demonstrate that the water proton resonance in small voxels is complicated, and is frequently composed of multiple well-resolved components (2–5). This inhomogeneous broadening is generally caused by local magnetic susceptibility gradients that reflect local anatomy and physiology. Previous work in this laboratory showed that effects of contrast agents in very small image voxels are often spectrally inhomogeneous (2–5). This reflects effects of the contrast agent in different sub-voxelar, perhaps microscopic environments (2–4). For example, small areas with high angiogenic activity in tumors may be detectable with increased sensitivity in HiSS images, because the water signal from these regions may be slightly shifted relative to the water signal from the rest of the voxel. The purpose of these experiments was to image contrast media uptake in breast lesions using HiSS MRI. MATERIALS AND METHODS
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