Spectral nature, antifungal activity and molecular structure of metal complexes of acetylpyrazine 4N-substituted thiosemicarbazones

Abstract

Nickel(II) and copper(II) complexes of acetylpyrazine 3-azabicyclo[3.2.2]-nonylthiosemicarbazone and nickel(II) complexes of acetylpyrazine 4N-methyl-, 4N-dimethyl-, and 3-hexamethyleneiminylthiosemicarbazone have been synthesized and characterized by their spectral and physical properties. Crystal structures for the nickel(II) complexes of the 4N-methyl- and 4N-dimethyl-derivatives, with a chloro ligand in the fourth coordination position, are included. The growth inhibition by the four thiosemicarbazones and their metal complexes against two human pathogenic fungi, Aspergillus niger and Paecilomyces variotii, have been evaluated.