Abstract
Hippocampal EEG was recorded from eight patients with intractable temporal lobe epilepsy who had depth electrodes implanted as part of their presurgical evaluation. The patients all had a mesial temporal seizure onset (5L, 3R) demonstrated by multiple ictal EEG recordings. A bipolar montage consisting of ascending pairs of contacts on the hippocampal electrodes was employed. EEG was recorded during two states: eyes-closed resting and behavioral activation (i.e., eyes-open, paired associate, verbal memory task). Hippocampal EEG power uniformly decreased during behavioral activation. The percent decrease in spectral power was greater for the nonepileptogenic hippocampi than the epileptogenic hippocampi in six of eight patients. The results demonstrate response of the human hippocampal EEG to behavioral activation. Similar techniques may have utility in the preoperative evaluation for epilepsy surgery.
Published Version
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