Abstract
Seaweeds are a major marine resource that can be explored to develop novel pharmaceutical molecules. The present study showed the presence of unique bioactive components in the petroleum ether extract (PEE) and methanolic extract (ME) of Sargassum tenerrimum. The gas chromatography-mass spectrometry analysis suggested that the PEE of S. tenerrimum contained antibacterial biomolecules: hexadecanoic acid, methyl ester, 17-pentatriacontene, dasycarpidan-1-methanol, and acetate (ester). However, the ME of S. tenerrimum exhibited better antibacterial effect than the PEE due to the presence of the bioactive compounds 1,2-benzenedicarboxylic acid, diisooctyl ester, tetratetracontane, 1-docosene, 1,2-benzenediol, and benzoic acid. Thus, promising antibacterial molecules can be isolated from S. tenerrimum for better therapeutic use.
Highlights
The pharmaceutical importance of seaweeds has been gaining attention in recent years among various researchers globally (Salehi et al, 2019; Maria et al, 2016)
Our results suggested the presence of the following compounds, benzoic acid, 3,5-dicyclohexyl-4-hydroxyester, and a unique methyl ester, called methyl 3,5-dicyclohexyl4-hydroxybenzoate, having a retention time of 63.37 min
A similar compound has been reported in the methanolic extract of Buchholzia Coriacea Engler with a retention time of 48.65 min (Chukwunonye et al, 2015)
Summary
The pharmaceutical importance of seaweeds has been gaining attention in recent years among various researchers globally (Salehi et al, 2019; Maria et al, 2016). Seaweeds constitute a significant resource from which secondary metabolites can be isolated; those that have specific pharmaceutical properties (Namvar et al, 2014; Bhutiya et al, 2018). Agardh belonging to the Sargassaceae family, commonly found in the Red Sea, Jazan province, Jazan, Kingdom of Saudi Arabia (KSA), can be studied to develop novel pharmaceutical molecules. To the best of our knowledge, there are very few scientific publications on the pharmaceutical value of S. tenerrimum. A study reported that the methanolic extract of S. tenerrimum contains steroids, saponins, alkaloids, tannins, flavonoids, terpenoids proteins, and phenolic compounds (Kumar et al, 2012). In continuation of our earlier works (Moni et al, 2019; Moni et al, 2018), the present study was designed to characterize the bioactive principles found in S. tenerrimum using gas chromatography-mass spectrometry (GC-MS)
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