Abstract
The structural requirement of the prostaglandin D 2 molecule for binding to the synaptic membrane fraction of rat brain was extensively studied by using various prostaglandin D derivatives. Most strict specificity was found in the structures of the cyclo-pentane ring and the double bond in 13,14-position. The addition and deprivation of the double bond in α- and ω-chain, except on 13,14-position, moderately affected the binding. The modification in the car☐yl terminus and ω-chain terminus did not seriously influence the binding. BW 245C and 9-β-prostaglandin D 2, potent agonists for the prostaglandin D 2 receptor in the platelet membrane, were almost ineffective. [ 3H]prostaglandin D 2 binding was not affected by the addition of various neuroactive substances to the binding assay mixture. Further, prostaglandin D 2 did not affect the known neurotransmitter receptor bindings in the rat brain.
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