Abstract
In a study of changes in the proteins, glycosaminoglycans and glycoprotein sugars in the cytosol and membrane fractions of rat and human brain during aging, the glycosaminoglycans were found to decrease in cytosol and increase in the membrane-bound fractions, while the glycoprotein sugars, not significantly changed in rat brain, decreased in human gray and more evidently in white matter. Changes in the sugar molar ratio were also found. The membrane hypothesis of aging is discussed in the light of these data.
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