Abstract
This chapter analyzes specificity of pathogenesis of infectious diseases. The human body could be considered as a growth medium for the microbe; whatever harm it causes is incidental to the growth of the microbe and its release from the body in viable form. Specificity of the harm done would depend on the metabolic products liberated during its growth in the body. A primary consideration of the human body might reveal specific pathophysiological responses to microbial infection. The responses might represent clinical disease entities. Specific pathogenic action can only be understood in terms of a dynamic host–parasite relationship. The chapter describes species specificity. Neisseria gonorrhea and meningitidis are limited to man. Babesia bovis occurs in cattle only. Trichomonas fetus causes disease in cattle and deer. Corynebacterium renale affects cattle only. Viruses show similar specific relationship with human and animal hosts. Among Salmonellae, S. pullorum affects poultry, S. dublin is more common in cattle, and S. typhi occurs in man.
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