Abstract
Regulated intracellular membrane fusion requires SNARE proteins, Rab GTPases, and several chaperones including Sec17/αSNAP, Sec18/NSF, and SM proteins. In the model vacuolar membrane fusion system, it was recently found that the Rab Ypt7 stimulates the SM protein complex HOPS to catalyze SNARE complex assembly directly, and that this stimulation requires a certain lipid composition in the membrane. In this study, we present the effects of the 8 major lipids in the vacuolar membrane on several sub-reactions of membrane fusion.
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