Abstract
Employing a 5lCr release cytotoxicity microassay, (J.Immunol. 110:1502, 1973) four patients.with documented SSPE were evaluated for cellular and humoral immunity to both measles and SSPE viruses. Labeled target cells were derived from a WI-38 line persistently infected with Edmonston B measles virus, a MA-160 line persistently infected with SSPE virus and uninfected control cells.Washed peripheral lymphocytes from SSPE patients and control donors exhibited comparable cytotoxicity to both infected cell lines. Serum and cerebrospinal fluid from SSPE patients inhibited the lymphocyte response to SSPE infected cells but did not significantly alter the response to measles infected cells for either SSPE or control lymphocytes. Moreover, fresh whole serum alone from control donors produced significant 51Cr release from both cell lines while SSPE whole sera was effective only against measles infected target cells.Preliminary characterization of the serum inhibitory factor suggested that it is associated with a high molecular weight IgM or antigen-antibody complex.These data also suggest antigenic differences between the SSPE and measles viruses.
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