Abstract
The effect of dietary lard and corn oil-supplementation on rat aortic 6-keto-PGF 1α synthesis from both exogenous and endogenous arachidonic acid was investigated. Only lard-supplementation resulted in any change when compared to rats fed normal chow. Lard-supplementation resulted in both a significant increase in the conversion of exogenous arachidonic acid to 6-keto-PGF 1α and a significant decrease in the ratio of linoleate to arachidonate in aortic phospholipids. Basal aortic synthesis of 6-keto-PGF 1α from endogenous arachidonic acid was not different for any group. We conclude that at least for the aortic conversion of exogenous arachidonic acid to 6-keto-PGF 1α the level of inhibitor linoleic acid in tissue phospholipids may be important.
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