Abstract
On isolated rabbit mesenteric arteries pretreated with phenoxybenzamine (10-5M) and contracted with prostaglandin F 2α (PGF 2α) dopamine (10 −6M to 3×10 −4M) and isoprenaline (10-9M to 10-5M) caused a dose-related relaxation. Pindolol (10 −7M) significantly suppressed the effects evoked by isoprenaline, but did not affect those produced by dopamine. The dopamine receptor antagonist metoclopramide (5×10 −5 and 10 −4M), however, shifted the dose-response curve for dopamine-induced relaxation significantly to the right in a concentration dependent manner without affecting relaxations caused by isoprenaline or papaverine. These results demonstrate for the first time a specific antagonism to dopamine-induced relaxation on rabbit mesenteric arteries in vitro . They support the hypothesis of the existence of specific dopamine receptors in vascular smooth muscles.
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