Abstract
Dopamine caused dose-related relaxations in helical strips of dog coronary, renal, mesenteric, cerebral and distal femoral arteries treated with high concentrations of phenoxybenzamine and contracted with prostaglandin F2α or K+ but not in proximal femoral arteries, the relaxation of these arteries being appreciably different. Epinine exerted dopamine-like arterial relaxations. Beta-adrenergic, cholinergic, histaminergic H2 and adenosine-related mechanisms are not involved in the dopamine-induced relaxation. Droperidol specifically attenuated the vascular action of dopamine. These results strongly support the presence of specific dopamine receptors in the dog arterial smooth muscle.
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